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One standard.
Three panels.

Hormones, neurodegeneration, metabolism. Different clinical domains, the same discipline: graded evidence, visible reasoning, and licensed sign-off on every report.

HRT decision support
APEX™
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Neurodegeneration
CASCADE™
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Amino acid metabolomics
AminoLogic
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APEX™ · HRT decision support

Two reports. One confident prescription.

Hormone therapy asks the same hard questions every time: which route is safe, at what dose, and is it working? APEX answers them in two passes. APEX Gene™ settles the fixed genetic questions once, before the first prescription. APEX™ then reads the living hormone picture at every follow-up, each recommendation shown with its formula, values, evidence grade, and citation.

One-time · pharmacogenomic

APEX Gene™

HRT Genetic Advisory Report

8 SNPs

Settle the questions that never change. A single 8-SNP test tells you the safe estrogen route and the genetic profile you are prescribing into, before the first script is written.

Estrogen route decision
Transdermal estradiol preferred

F2 heterozygous + family history of VTE. Oral estrogen carries substantially higher VTE risk in carriers.

HRT safety profile
High concern
Bone protection
Low concern
F5 Factor V Leiden G/G · wild type
F2 Prothrombin G20210A G/A · ~3-4× VTE
COMT Val158Met Val/Met · ~40% ↓ clearance
  • 01 Estrogen route: oral, transdermal, or referral
  • 02 Folate: folic acid vs methylfolate (MTHFR)
  • 03 Estrogen clearance: dosing caution (COMT, CYP1B1)
  • 04 Bone: vitamin D dosing and DXA (VDR)
Order a panel 6 pages · one-time
Ongoing · dual-matrix

APEX™

Advanced Panel for Estrogen & Hormone Expression

28 ASSAYS

Then watch the living picture. Across serum, first-morning urine, and a 6-point saliva curve, APEX shows how each patient actually metabolises estrogen, and whether the plan is working.

Executive dashboard · 6 systems
Estrogens & Pg HPA / cortisol Phase I metab. Androgens Phase II methyl. Methylation cyc.
2:16 ratio (protective) 70.3
Methylation index (COMT) 0.26
Pg:E2 ratio
3.1 ↓ dominance
Homocysteine
10.4 μmol/L
  • · Estrogen metabolism, Phase I → II
  • · 6-point salivary cortisol & CAR
  • · Pg:E2 and Free T, cycle-adjusted
  • · Homocysteine & Methylation Index
Order a panel 14 pages · every 3-12 mo

One map, drawn once. One instrument, read often.

01
Sequence the genome once

APEX Gene™ locks the estrogen route and flags MTHFR, COMT, and VDR before you prescribe.

02
Prescribe with the route decided

Dose is informed by the patient's genetic clearance capacity, not a default assumption.

03
Monitor with APEX™

Homocysteine and the Methylation Index confirm the supplementation is actually working.

CASCADE™

Three biomarkers. One honest read.

A plasma panel for Alzheimer-type pathology. CASCADE reports pTau217, the Aβ42/40 ratio, and a cross-platform composite against platform-specific cutoffs, then reads them for concordance under the 2024 Alzheimer's Association criteria. It calls borderline borderline, checks renal function before it trusts a value, and tells you exactly when to confirm with amyloid PET or CSF. It supports the diagnosis. It never makes it.

Lumipulse G · pTau217
0.395 pg/mL
POSITIVE ≥ 0.325

The single most accurate AD blood biomarker. Rises as tau tangles form.

Sysmex HISCL · Aβ42/40
0.092
BORDERLINE 0.090-0.102

Amyloid ratio, lower is abnormal. eGFR-independent. AUC 0.94.

Composite · exploratory
0.018
NEGATIVE ≤ 0.022

pTau217/Aβ42 concordance. Cross-platform, labelled exploratory.

Isolated · 1 of 3
One positive. Repeat or confirm with CSF / amyloid PET.
AT1 classification · 2024 AA
A+/- T1+
Partial positivity. One core biomarker positive.
APOE · ARIA risk
ε3/ε3 · low
No ε4 allele. Standard monitoring if treating.
eGFR 48 · mild, Aβ42/40 stays valid Anti-amyloid support: not established Platform-specific cutoffs HCP sign-off required
Order a panel
AminoLogic
41-analyte plasma panel · LC-MS
IEM CLEAR
33
Normal
8
Elevated
0
Reduced
Leucine Leu 416.7 ↑ 203% URL
Glutamine Gln 774.5 ↑ 103%
Fischer ratio BCAA/AAA 3.83
bcaa_elevation insulin_resistance arginase_overactivity
AminoLogic

Forty-one analytes, mapped to how the body actually runs.

A fasting plasma amino-acid panel read by mass spectrometry. AminoLogic rules out inborn errors of metabolism first, then maps the profile across seven longevity systems and roughly twenty validated ratios, from Fischer and GABR to the Wang DM index, each with its formula, inputs, and citation on the page.

Muscle & anabolic
EAA/NEAA · 3-MeHis
Metabolic flexibility
Gly/BCAA · DM index
Nitric oxide & vascular
GABR · Orn/Cit
Redox & collagen
Cystine · Hyp/Pro
41
Analytes
7
Longevity systems
20+
Metabolic ratios
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The standard behind all three.

Whatever the panel, the epistemics do not change. Every product is held to the same four commitments.

01

Reasoning is shown

Every recommendation displays its triggering values, the formula, the reference range, and the citation.

02

Evidence is graded

Trial-grade evidence and expert consensus are labelled as what they are, following OCEBM 2011 and GRADE.

03

The clinician signs off

No report is released for clinical use without licensed HCP review. These tools support judgment, never replace it.

04

Data is protected

HIPAA, GDPR Article 9, and the EU AI Act high-risk provisions are the baseline for every deployment.

CDSS HCP ONLY HIPAA GDPR ART. 9 EU AI ACT · HIGH-RISK MDSW DOES NOT DIAGNOSE

Put a sample report in front of your team.

Request a demonstration of APEX™, CASCADE™ or AminoLogic, or download a full sample report for each panel.

Request a demo About Novlogics